Methylamine → HCID 13690889, compound
Reaction equation
[CH3:1][NH2:2].Cl[S:4]([C:7]1[CH:8]=[C:9]([C:17]([OH:19])=[O:18])[C:10]2[O:14][CH:13]([CH3:15])[CH2:12][C:11]=2[CH:16]=1)(=[O:6])=[O:5].[OH-].[Na+]>O>[CH3:1][NH:2][S:4]([C:7]1[CH:8]=[C:9]([C:17]([OH:19])=[O:18])[C:10]2[O:14][CH:13]([CH3:15])[CH2:12][C:11]=2[CH:16]=1)(=[O:6])=[O:5]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 5 °C
Procedure
108 g of a 40% aqueous solution of methylamine and 108 ml of water were added into a 2-liter round-bottomed flask. The contents were cooled to 5° C. and 193 g of 5-chlorosulphonyl-2-methyl-2,3-dihydrobenzofuran-7-carboxylic acid were then added in portions of 10 g, while cooling in an ice and salt bath so as to maintain the temperature at 5° C. After each addition of acid, 14.5 ml of a solution containing 140 ml of 30% sodium hydroxide in 140 ml of water were added.
Workup
- temperatureto maintain the temperature at 5° C
- additionwere added
Sources & evidence
- ORD record
- ord-b728dca0f87544b099b0a4820d1f2ea1
- Source dataset
- uspto-grants-1991_04
- Patent number
- US05006570
Reaction notes
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