Acetic Acid → HCID 13983508, compound

HRID 1084925Notes

Reaction equation

HRID 1084925 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([C:15]([OH:17])=[O:16])[C:8]2[O:12][CH:11]([CH3:13])[CH2:10][C:9]=2[CH:14]=1)(=O)=O.C(O)(=O)C.[Sn].Cl>O>[SH:2][C:5]1[CH:6]=[C:7]([C:15]([OH:17])=[O:16])[C:8]2[O:12][CH:11]([CH3:13])[CH2:10][C:9]=2[CH:14]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 5352426Tin atom2×HCID 13983503HCID 13983503, compound

Product 1

HCID 13983508HCID 13983508, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

216 g of 5-chlorosulphonyl-2-methyl-2,3,-dihydrobenzofuran-7-carboxylic acid, 585 ml of acetic acid and 348 g of tin were introduced into a 6-liter round-bottomed flask and 1560 ml of concentrated hydrochloric acid (d =1.18) were then added dropwise, while maintaining the temperature between 45° and 55° C. The contents were then heated for 2 hours at 55°-60° C. until the tin was completely dissolved, and the solution which was poured into 12 liters of water was then filtered. The crystals formed were drained, washed with water and dried at 40° C.

Workup

  1. temperaturewhile maintaining the temperature between 45° and 55° C
  2. dissolutionwas completely dissolved
  3. filtrationwas then filtered
  4. customThe crystals formed
  5. washwashed with water
  6. customdried at 40° C.

Sources & evidence

ORD record
ord-590554103c9b43d799158b3dc305a590
Source dataset
uspto-grants-1991_04
Patent number
US05006570

Reaction notes

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