1-(1-Cyclohexen-1-ylmethyl)pyrrolidine-2-methylamine → HCID 13983532, compound

HRID 1084935Notes

Reaction equation

[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10][CH:9]2[CH2:13][NH2:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.[Cl:15][C:16]1[CH:17]=[C:18]2[C:23](=[C:24]([C:26](Cl)=[O:27])[CH:25]=1)[O:22][CH2:21][CH2:20][CH2:19]2>C(C(C)=O)C>[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10][CH:9]2[CH2:13][NH:14][C:26]([C:24]2[CH:25]=[C:16]([Cl:15])[CH:17]=[C:18]3[C:23]=2[O:22][CH2:21][CH2:20][CH2:19]3)=[O:27])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

Participants

Conditions

Temperature: 5 °C

Procedure

101 g of 1-cyclohexenylmethyl-2-aminomethylpyrrolidine and 200 ml of methyl ethyl ketone were introduced into a 2-liter round-bottomed flask. The contents were cooled to 5° C. and a solution of 109 g of 6-chlorochroman-8-carbonyl chloride in 500 ml of methyl ethyl ketone was added dropwise, while maintaining the temperature between 0° and 5° C.

Workup

temperaturewhile maintaining the temperature between 0° and 5° C.

Sources & evidence

ORD record: ord-40621e3631d946a6a79de0467ecbc44f
Source dataset: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05006570

Reaction notes

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