反应详情

[2-[(6-Bromohexyl)oxy]ethyl]benzene (4.0 g) was added dropwise to benzylamine (20 ml) at 110°. The solution was heated at 110°-120° for 90 min, cooled, and treated with hydrochloric acid (2M; 125 ml). The mixture was extracted with EA (2×100 ml) and the extract was washed with aqueous sodium carbonate (100 ml) and brine (100 ml), dried and evaporated. Distillation of the residue gave the title compound as a colourless oil (3.2 g) b.p. 180°-190°/0.1 mmHg. T.l.c. (CX-ER 1:1) Rf 0.25.

1. temperatureThe solution was heated at 110°-120° for 90 min
2. temperaturecooled
3. extractionThe mixture was extracted with EA (2×100 ml)
4. washthe extract was washed with aqueous sodium carbonate (100 ml) and brine (100 ml)
5. customdried
6. customevaporated
7. distillationDistillation of the residue