反应详情

To a stirred solution of 2.52 grams (g) (0.0078 moles) of N-(3-(((2,6-dichloro-3-methylphenyl)amino)sulfonyl)-1H-1,2,4-triazol-5-yl)amine in 100 milliliters (mL) of dry acetonitrile under nitrogen was added 1.5 g (0.01 moles) of freshly distilled malonyl chloride. The mixture was stirred at ambient temperature overnight (14 hr) and a yellow precipitate formed. The solid product was collected by filtration and dried; mp 280°-282° C. (decomposes). The filtrate was found to contain additional product which was recovered by concentrating the filtrate to dryness. The combined yield of product was 2.58 g (85 percent yield).

1. customa yellow precipitate formed
2. filtrationThe solid product was collected by filtration
3. customdried
4. customwas recovered
5. concentrationby concentrating the filtrate to dryness