反应详情

440 mg of sodium hydride solution (concentration 40%) was added portionwise to 30 ml of ethylene glycol. After abating of the froth occurred, 50 mg of cuprous chloride, 75 mg of 8-hydroxyquinoline and 1.07 g of 2-bromo-1-acetylamino-benzene were added to the solution and the mixture was heated at 70° to 80° C. for 50 minutes. The reaction mixture was treated in a usual manner, and then crystallization was effected from a solvent mixture of n-hexane and ethyl acetate to give 720 mg of the desired compound. Yield: 74%, melting point: 89°-91° C.

1. temperaturethe mixture was heated at 70° to 80° C. for 50 minutes
2. additionThe reaction mixture was treated in a usual manner
3. customcrystallization
4. additionwas effected from a solvent mixture of n-hexane and ethyl acetate