2-[[(Ethoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methylvaleric acid → (2-Oxoazacyclotridecan-3-yl)valeramide

HRID 1085004Notes

Reaction equation

HRID 1085004 reaction equation
C(OP(CC(CC(C)C)C(O)=O)(C[N:7]1[C:11](=[O:12])[C:10]2=CC=[CH:15][CH:16]=[C:9]2C1=O)=O)C.N[CH:28]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][C:30](=[O:41])[NH:29]1>>[O:41]=[C:30]1[CH:31]([CH:10]([CH2:9][CH2:16][CH3:15])[C:11]([NH2:7])=[O:12])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:28][NH:29]1

Participants

3

Reactant 2

HCID 200630162-[[(Ethoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methylvaleric acidHCID 21939029(-)-3-Amino-2-azacyclotridecanone

Product 1

HCID 131716207(2-Oxoazacyclotridecan-3-yl)valeramide

Procedure

In a manner analogous to that describe in Example 1(A)(iv), from 1.9 g of 2(RS)-[[(RS)-(ethoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methylvaleric acid and 1.0 g of (-)-3-amino-2-azacyclotridecanone, there were obtained 2.1 g of 2(RS)-[[(RS)-(ethoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methyl-N(R or S)-(2-oxoazacyclotridecan-3-yl)valeramide in the form of a white solid.

Sources & evidence

ORD record
ord-818fdfd3ca0344ccb2a536f23b681664
Source dataset
uspto-grants-1991_04
Patent number
US05006651

Reaction notes

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