1-Chloro-2-(diethylamine)ethane hydrochloride → 4(3H)-Quinazolinone, 2-((2-(diethylamino)ethyl)thio)-3-phenyl-

HRID 1085056Notes

Reaction equation

HRID 1085056 reaction equation
[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl.[CH2:20]([N:22]([CH2:26][CH3:27])[CH2:23][CH2:24]Cl)[CH3:21]>>[CH2:20]([N:22]([CH2:26][CH3:27])[CH2:23][CH2:24][S:1][C:2]1[N:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[CH3:21]

Participants

3

Reactant 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 178515047HCID 178515047, compound

Product 1

HCID 637434(3H)-Quinazolinone, 2-((2-(diethylamino)ethyl)thio)-3-phenyl-Yield 32.7%

Procedure

The title compound was prepared in a yield of 32.7%, using 2-mercapto-3-phenyl-4(3H)-quinazolinone in place of 3-isobutyl-2-mercapto-4(3H)-quinazoline and β-diethylaminoethyl chloride hydrochloride in place of 2-chloromethylpyridine hydrochloride.

Sources & evidence

ORD record
ord-e075142c14de418cb611548f5aa51646
Source dataset
uspto-grants-1991_04
Patent number
US05008266

Reaction notes

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