2-Chloromethylbenzimidazole → 2-(2-Benzimidazolylmethylthio)-3-phenyl-4(3H)-quinazolinone

HRID 1085058Notes

Reaction equation

HRID 1085058 reaction equation
[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl[CH2:20][C:21]1[NH:22][C:23]2[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=2[N:25]=1>>[N:22]1[C:23]2[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=2[NH:25][C:21]=1[CH2:20][S:1][C:2]1[N:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 785712-ChloromethylbenzimidazoleHCID 178515047HCID 178515047, compound

Product 1

HCID 122142452-(2-Benzimidazolylmethylthio)-3-phenyl-4(3H)-quinazolinoneYield 39.3%

Procedure

The title compound was prepared in a yield of 39.3%, using 2-mercapto-3-phenyl-4(3H)-quinazolinone in place of 3- isobutyl-2-mercapto-4(3H)-quinazolinone and 2-chloromethylbenzimidazole in place of 2-chloromethylpyridine hydrochloride.

Sources & evidence

ORD record
ord-b9af2cff4abf438e8dc59d94559db318
Source dataset
uspto-grants-1991_04
Patent number
US05008266

Reaction notes

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