2-(Bromomethyl)thiophene → 3-Phenyl-2-(2-thienylmethylthio)-4(3H)-quinazolinone

HRID 1085060Notes

Reaction equation

HRID 1085060 reaction equation
[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:20][C:21]1[S:22][CH:23]=[CH:24][CH:25]=1>>[C:12]1([N:11]2[C:10](=[O:18])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]2[S:1][CH2:20][C:21]2[S:22][CH:23]=[CH:24][CH:25]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 118299782-(Bromomethyl)thiopheneHCID 178515047HCID 178515047, compound

Product 1

HCID 145751573-Phenyl-2-(2-thienylmethylthio)-4(3H)-quinazolinoneYield 37.4%

Procedure

The title compound was prepared in a yield of 37.4%, using 2-mercapto-3-phenyl-4(3H)-quinazolinone in place of 3- isobutyl-2-mercapto-4(3H)-quinazolinone and 2-bromomethylthiophene in place of 2-chloromethylpyridine hydrochloride.

Sources & evidence

ORD record
ord-dea8eee5e0fb4f94927724d9239bced9
Source dataset
uspto-grants-1991_04
Patent number
US05008266

Reaction notes

Loading…