2-(Chloromethyl)-4-methoxy-5-methylpyridine → 2-[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-3-phenyl4(3H)-quinazolinone

HRID 1085063Notes

Reaction equation

HRID 1085063 reaction equation
[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl[CH2:20][C:21]1[CH:26]=[C:25]([O:27][CH3:28])[C:24]([CH3:29])=[CH:23][N:22]=1>>[CH3:28][O:27][C:25]1[C:24]([CH3:29])=[CH:23][N:22]=[C:21]([CH2:20][S:1][C:2]2[N:11]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:10](=[O:18])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH:26]=1

Participants

3

Reactant 2

HCID 144799142-(Chloromethyl)-4-methoxy-5-methylpyridineHCID 178515047HCID 178515047, compound

Product 1

HCID 145751642-[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-3-phenyl4(3H)-quinazolinoneYield 22.5%

Procedure

The title compound was prepared in a yield of 22.5%, using 2-mercapto-3-phenyl-4(3H)-quinazolinone in place of 2- mercapto-6-methyl-3-phenyl-4(3H)-quinazolinone and 2-chloromethyl-4-methoxy-5-methylpyridine in place of 2-chloromethylpyridine hydrochloride.

Sources & evidence

ORD record
ord-5617cf84ff3d4c418ca2feda863d20a8
Source dataset
uspto-grants-1991_04
Patent number
US05008266

Reaction notes

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