2-(Chloromethyl)-4-methoxy-5-methylpyridine → 2[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-6-methyl-3-phenyl-4(3H)-quinazolinone

HRID 1085066Notes

Reaction equation

HRID 1085066 reaction equation
[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:19])[CH:8]=2)[N:3]=1.Cl[CH2:21][C:22]1[CH:27]=[C:26]([O:28][CH3:29])[C:25]([CH3:30])=[CH:24][N:23]=1>>[CH3:29][O:28][C:26]1[C:25]([CH3:30])=[CH:24][N:23]=[C:22]([CH2:21][S:1][C:2]2[N:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:10](=[O:18])[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([CH3:19])[CH:8]=3)[N:3]=2)[CH:27]=1

Participants

3

Reactant 2

HCID 144799142-(Chloromethyl)-4-methoxy-5-methylpyridineHCID 178423443HCID 178423443, compound

Product 1

HCID 145751702[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-6-methyl-3-phenyl-4(3H)-quinazolinoneYield 32.9%

Procedure

The title compound was prepared in a yield of 32.9%, using 2-mercapto-6-methyl-3-phenyl-4(3H)-quinazolinone in place of 2-mercapto-3-phenyl-4(3H)-quinazolinone and 2-chloromethyl-4-methoxy-5-methylpyridine in place of 2chloromethyl-4-methylpyridine hydrochloride.

Sources & evidence

ORD record
ord-dfd72a80dcb34bd8bbc072c2038e9d70
Source dataset
uspto-grants-1991_04
Patent number
US05008266

Reaction notes

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