反应详情

3-Cyclopentylpropionitrile is prepared in this example. 3-Cyclopentylpropionyl chloride (57.7 g, 0.36 mole) is added dropwise to a large excess of concentrated ammonium hydroxide (400 ml) cooled in an ice/salt bath. The heavy suspension of white solid is stirred overnight, collected by filtration, washed with cold water, and recrystallized from about 2 liters of boiling water. The lustrous white plates of the amide are dried in vacuo over P2O5 ; yield 31.6 g (62.3%); mp 122° C.

1. temperaturecooled in an ice/salt bath
2. additionThe heavy suspension of white solid
3. filtrationcollected by filtration
4. washwashed with cold water
5. customrecrystallized from about 2 liters of boiling water
6. dry with materialThe lustrous white plates of the amide are dried in vacuo over P2O5