Acetic Acid → HCID 178467921, compound

HRID 1085130Notes

Reaction equation

HRID 1085130 reaction equation
[NH2:1][C:2]1[C:12]2[N:11]=[C:10]([C:13]3[CH:18]=[CH:17][C:16]([N:19]4[C:27]5[CH:26]=[CH:25][N:24]=[CH:23][C:22]=5[N:21]=[C:20]4[CH3:28])=[CH:15][CH:14]=3)[CH2:9][C:8](=[O:29])[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(O)(=O)C.[C:34](OCC)(OCC)([O:36][CH2:37][CH3:38])[CH3:35]>>[CH2:34]([O:36][CH:37]([N:1]=[C:2]1[C:12]2[C:6]([NH:7][C:8](=[O:29])[CH2:9][CH:10]([C:13]3[CH:18]=[CH:17][C:16]([N:19]4[C:27]5[CH:26]=[CH:25][N:24]=[CH:23][C:22]=5[N:21]=[C:20]4[CH3:28])=[CH:15][CH:14]=3)[N:11]=2)=[CH:5][CH:4]=[CH:3]1)[CH3:38])[CH3:35]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 66221Triethyl orthoacetateHCID 20061015HCID 20061015, compound

Product 1

HCID 178467921HCID 178467921, compound

Procedure

A solution of the aniline from Example 14 (0.38 g, 1 mmol) and glacial acetic acid (0.5 ml) in triethyl orthoacetate (5 ml) was stirred at 25° C. for 72 hours. The product was filtered and recrystallised from toluene (60 mg, 13%).

Workup

  1. filtrationThe product was filtered
  2. customrecrystallised from toluene (60 mg, 13%)

Sources & evidence

ORD record
ord-1ebb9be81874448f97c22567c2620966
Source dataset
uspto-grants-1991_04
Patent number
US05008263

Reaction notes

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