p-Aminoacetophenone → 4-(4-Acetylphenyl)amino-3-nitropyridine hydrochloride

HRID 1085141노트

반응식

HRID 1085141 반응식
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10].[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:21])[CH3:20])=[CH:15][CH:14]=1>C(O)C>[ClH:2].[C:19]([C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:3]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N+:9]([O-:11])=[O:10])=[CH:14][CH:15]=1)(=[O:21])[CH3:20]

참가 물질

4

반응물 2

HCID 7468p-AminoacetophenoneHCID 122442064-Chloro-3-nitropyridine hydrochloride

생성물 1

HCID 197912824-(4-Acetylphenyl)amino-3-nitropyridine hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 4-chloro-3-nitropyridine hydrochloride (9.75 g, 50 mmol) in ethanol (40 ml) was added to a slurry of p-aminoacetophenone (6.76 g, 50 ml) in ethanol (25 ml), and the mixture was stirred at room temperature overnight. The mixture was chilled in ice, and the yellow solid filtered off and dried in vacuo. Yield 10.1 g (69%), m.p. 197°-200° C.

후처리

  1. temperatureThe mixture was chilled in ice
  2. filtrationthe yellow solid filtered off
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-7d87ee38471f4d4fa72360940ec368ba
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05008263

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