Ethanolamine → HCID 20061776, compound

HRID 1085233Notes

Reaction equation

C1(=O)OCCC1.[NH2:7][CH2:8][C:9](O)=O.[N:12]1([CH2:18][C:19]([OH:21])=O)[CH2:16][CH2:15][CH2:14][C:13]1=[O:17].C(CN)O>>[O:21]1[CH2:9][CH2:8][N:7]=[C:19]1[CH2:18][N:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]

Participants

Reactant 4

HCID 700Ethanolamine

HCID 750Glycine

HCID 7302Gamma-Butyrolactone

HCID 31466872-(2-Oxopyrrolidin-1-yl)acetic acid

Product 1

HCID 20061776HCID 20061776, compound

Procedure

1-[(2-oxazolin-2-yl)methyl]-2-pyrrolidone, for example, can be obtained by condensation of pyrrolidone and chloroacetic acid to form 2-pyrrolidone acetic acid, where m=1 in the above formula (II), or, alternatively, by condensing butyrolactone with glycine, and the starting carboxylic acid condensed with ethanolamine and cyclodehydrated to form 1-[(2-oxazolin-2-yl)methyl]-2-pyrrolidone.

Sources & evidence

ORD record: ord-f71c293f6dda4cf8985fd96dc4d36569
Source dataset: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05008367

Reaction notes

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