HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 1,3-dimethyl-6-{4-[2-(2-nitrophenyl)ethyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Nitrophenethyl bromide | HCID 12363878 | — |
| Reactant | 1,3-dimethyl-6-[3-(4-nitroanilino)propylamino]-2,4-(1H,3H)-pyrimidinedione | HCID 20061244 | — |
| Product | 1,3-dimethyl-6-{4-[2-(2-nitrophenyl)ethyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione | HCID 19011913 | — |
Reaction Steps
To 15 ml of isopropanol were added 3.0 g of the above prepared compound 11, 3.2 g of 1,3-dimethyl-6-(piperazine-1-yl)-2,4(1H,3H)-pyrimidinedione (compound 2) and 4.2 ml of triethylamine, and the resulting mixture was then treated by the same procedure as in Example 2 in order to obtain 2.2 g of 1,3-dimethyl-6-{4-[2-(2-nitrophenyl)ethyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05008267 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-54b53b4a5fcc4c0ea112fb03694c02cf |
| Source note | uspto-grants-1991_04 |