HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-(2-Bromoethyl)-p-nitrobenzamide | HCID 458985 | — |
| Reactant | 1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione | HCID 12816873 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione | HCID 12816873 | — |
| Product | 1,3-dimethyl-6-[4-(4-nitrophenyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione | HCID 20061078 | — |
Reaction Steps
A mixture of 1.3 g of the compound 46 obtained in the paragraph (1), 1.8 g of 1,3-dimethyl-6-(1-piperazinyl)-2,4(1H,3H)pyrimidinedione (compound 37), 1.3 ml of triethylamine and 10 ml of isopropanol was heated under reflux for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05008267 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-2bd4fbbbc3894fdaabbf7c5db9213d68 |
| Source note | uspto-grants-1991_04 |