Ethanol → HCID 20061248, compound

HRID 1085266Notes

Reaction equation

HRID 1085266 reaction equation
C(O)C.[OH:4][CH2:5][CH2:6][NH:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)[CH2:12][CH2:11]1.Cl[C:26]1[N:31]([CH3:32])[C:30](=[O:33])[N:29]([CH3:34])[C:28](=[O:35])[CH:27]=1>C(N(CC)CC)C>[CH3:32][N:31]1[C:26]([N:7]([CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][N:13]([C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=3)[CH2:14][CH2:15]2)[CH2:6][CH2:5][OH:4])=[CH:27][C:28](=[O:35])[N:29]([CH3:34])[C:30]1=[O:33]

Participants

5

Reactant 3

HCID 702EthanolHCID 814426-Chloro-1,3-dimethyl-2,4(1H,3H)-pyrimidinedioneHCID 20061133HCID 20061133, compound

Product 1

HCID 20061248HCID 20061248, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To 10 ml of ethanol were added 1.0 g of the thus obtained compound 75, 0.52 g of 6-chloro-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione and 2 ml of triethylamine as starting materials, and the resulting mixture was treated in the same procedure as in Example 39-(2) to obtain 0.73 g of 1,3-dimethyl-6-{N-(2-hydroxyethyl)-2-[4-(4-nitrophenyl)piperazin-1-yl]ethylamino}-2,4(1H,3H)-pyrimidinedione.

Sources & evidence

ORD record
ord-ebdb89b4de0343e08751783fb5b1f48e
Source dataset
uspto-grants-1991_04
Patent number
US05008267

Reaction notes

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