HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloro-4-nitrobenzene → 1,3-dimethyl-6-{4-[3-(2-chloro-4-nitroanilino)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloro-4-nitrobenzene | HCID 7443 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-dimethyl-6-{4-[3-(N-ethanesulfonyl-4-nitroanilino)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione | HCID 20061072 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1,3-dimethyl-6-{4-[3-(2-chloro-4-nitroanilino)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione | HCID 20061247 | 155.7% |
Reaction Steps
A mixture consisting of 0.4 g of Compound 158 obtained in Example 99-(1), 0.4 g of 3,4-dichloro-nitrobenzene, 0.43 ml of triethylamine and 6 ml of dimethylformamide was treated in a manner similar to Example 99-(2), thereby obtaining 0.55 g of 1,3-dimethyl-6-{4-[3-(2-chloro-4-nitroanilino)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05008267 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-45f9cada9c2e4d18ab79196b2e09ebfc |
| Source note | uspto-grants-1991_04 |