HCID 20061108, compound → HCID 20061225, compound

HRID 1085292Notes

Reaction equation

HRID 1085292 reaction equation
[CH3:1][N:2]1[C:7]([NH:8][CH2:9][CH2:10][N:11]([CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=2)C(OC(C)(C)C)=O)=[CH:6][C:5](=[O:31])[N:4]([CH3:32])[C:3]1=[O:33].[ClH:34].O1CCOCC1>>[ClH:34].[CH3:1][N:2]1[C:7]([NH:8][CH2:9][CH2:10][NH:11][CH2:19][CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]([N+:28]([O-:30])=[O:29])=[CH:26][CH:27]=2)=[CH:6][C:5](=[O:31])[N:4]([CH3:32])[C:3]1=[O:33]

Participants

3

Reactant 2

HCID 20061108HCID 20061108, compound2×HCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 20061225HCID 20061225, compound

Procedure

30 ml of 0.5 N HCl/dioxane were added to 4.9 g of 1,3-dimethyl-6-{2-[N-(t-butoxycarbonyl)-3-(4-nitrophenyl)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione (Compound 173). The resultant mixture was stirred at room temperature for 24 hours. Precipitated crystals were collected by filtration and then washed with a chilled solvent consisting of a 1:2 mixture (by volume) of ethanol and ether, thereby obtaining 3.9 g of 1,3-dimethyl-6-{2-[3-(4-nitrophenyl)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione hydrochloride (Compound e).

Workup

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. washwashed with a chilled solvent

Sources & evidence

ORD record
ord-41b9fd4a26f74576af633e1a33bd5d80
Source dataset
uspto-grants-1991_04
Patent number
US05008267

Reaction notes

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