HCID 20061108, compound → HCID 20061225, compound

Participants

Reaction Steps

30 ml of 0.5 N HCl/dioxane were added to 4.9 g of 1,3-dimethyl-6-{2-[N-(t-butoxycarbonyl)-3-(4-nitrophenyl)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione (Compound 173). The resultant mixture was stirred at room temperature for 24 hours. Precipitated crystals were collected by filtration and then washed with a chilled solvent consisting of a 1:2 mixture (by volume) of ethanol and ether, thereby obtaining 3.9 g of 1,3-dimethyl-6-{2-[3-(4-nitrophenyl)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione hydrochloride (Compound e).

Provenance & Evidence