Potassium Carbonate → HCID 20061430, compound

Participants

Reaction Steps

6-(2-methanesulfonyloxyethylamino)-1,3-dimethyl-5-nitro-2,4(1H,3H)-pyrimidinedione (5.8 g) was dissolved in 70 ml of acetonitrile and added with 3.8 g of potassium carbonate. The reaction was carried out under heating with reflux for 3 hours. The reaction mixture as cooled down to room temperature; insoluble materials were removed by filtration. The filtrate was concentrated to a volume of 20 ml, added with 100 ml of ether and then stored refrigerated for 2 days. Crystals formed were collected by filtration and washed with hexane; thus 1.0 g of a powdery compound, 6-aziridin-1-yl)-1,3-dimethyl-5-nitro-2,4(1H,3)-pyrimidinedione, was obtained.

Provenance & Evidence