Potassium Carbonate → HCID 20061430, compound

HRID 1085296Notes

Reaction equation

HRID 1085296 reaction equation
CS(O[CH2:6][CH2:7][NH:8][C:9]1[N:14]([CH3:15])[C:13](=[O:16])[N:12]([CH3:17])[C:11](=[O:18])[C:10]=1[N+:19]([O-:21])=[O:20])(=O)=O.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[N:8]1([C:9]2[N:14]([CH3:15])[C:13](=[O:16])[N:12]([CH3:17])[C:11](=[O:18])[C:10]=2[N+:19]([O-:21])=[O:20])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 20061394HCID 20061394, compound

Product 1

HCID 20061430HCID 20061430, compoundYield 24.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

6-(2-methanesulfonyloxyethylamino)-1,3-dimethyl-5-nitro-2,4(1H,3H)-pyrimidinedione (5.8 g) was dissolved in 70 ml of acetonitrile and added with 3.8 g of potassium carbonate. The reaction was carried out under heating with reflux for 3 hours. The reaction mixture as cooled down to room temperature; insoluble materials were removed by filtration. The filtrate was concentrated to a volume of 20 ml, added with 100 ml of ether and then stored refrigerated for 2 days. Crystals formed were collected by filtration and washed with hexane; thus 1.0 g of a powdery compound, 6-aziridin-1-yl)-1,3-dimethyl-5-nitro-2,4(1H,3)-pyrimidinedione, was obtained.

Workup

  1. temperatureunder heating
  2. temperaturewith reflux for 3 hours
  3. custominsoluble materials were removed by filtration
  4. concentrationThe filtrate was concentrated to a volume of 20 ml
  5. additionadded with 100 ml of ether
  6. customCrystals formed
  7. filtrationwere collected by filtration
  8. washwashed with hexane

Sources & evidence

ORD record
ord-812fe36c328c403cb08dc14fe056fcbb
Source dataset
uspto-grants-1991_04
Patent number
US05008267

Reaction notes

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