Water → HCID 20061328, compound

HRID 1085299Notes

Reaction equation

HRID 1085299 reaction equation
C1(C)C=CC(S(O[CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=2)(=O)=O)=CC=1.[OH:24][CH2:25][CH2:26][CH2:27][NH2:28].O.C(Cl)(Cl)Cl>O1CCOCC1>[OH:24][CH2:25][CH2:26][CH2:27][NH:28][CH2:11][CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6212Chloroform2×HCID 90863-Amino-1-propanolHCID 12918159HCID 12918159, compound

Product 1

HCID 20061328HCID 20061328, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

3-(4-nitrophenyl)propyl p-toluenesulfonate (1 g) and 4.1 ml of 3-hydroxypropylamine were dissolved in 10 ml of dioxane and the solution was stirred at 80° C. for 30 minutes. To the solution was added 100 ml of water and 100 ml of chloroform, and the mixture was thoroughly mixed for separation. The chloroform-layer fraction was taken, washed with water and then dried over sodium sulfate anhydrous. The solvent was removed in vacuo and 0.7 g of an oil of N-(3-hydroxypropyl-3-(4-nitrophenyl)propylamine was obtained.

Workup

  1. additionthe mixture was thoroughly mixed for separation
  2. washwashed with water
  3. dry with materialdried over sodium sulfate anhydrous
  4. customThe solvent was removed in vacuo and 0.7 g of an oil of N-(3-hydroxypropyl-3-(4-nitrophenyl)propylamine
  5. customwas obtained

Sources & evidence

ORD record
ord-b56090113026488d8638f215fb691b94
Source dataset
uspto-grants-1991_04
Patent number
US05008267

Reaction notes

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