4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid → Quinine

Participants

Reaction Steps

0.5 ml of diethyl ether containing egg phosphatidylcholine at a concentration of 100 mg/ml and 0.3 ml quinine-HCl solution at 40 mg/ml of Hepes buffer (pH 7.2) were mixed and sonicated while evaporating the ether with a stream of nitrogen. This process and the subsequent steps in prepartion of liposomes was done as described for chloroquine liposomes Example 1. The entrapment of quinine in liposomes was 48.5%.

Provenance & Evidence