1-(1-Naphthyl)piperazine → 3-Ethylthio-5-fluoro-3-(2-[4-(1-naphthyl)-1-piperazinyl]ethyl}-1,3-dihydro-2(2H)-indolone

HRID 1085403Notes

Reaction equation

HRID 1085403 reaction equation
[C:1]1([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(C1C=CC(C)=CC=1)(O)(=O)=O.[CH2:28]([S:30][C:31]1([CH2:42][CH2:43]O)[C:39]2[C:34](=[CH:35][CH:36]=[C:37]([F:40])[CH:38]=2)[NH:33][C:32]1=[O:41])[CH3:29]>>[CH2:28]([S:30][C:31]1([CH2:42][CH2:43][N:14]2[CH2:15][CH2:16][N:11]([C:1]3[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH:4]=[CH:3][CH:2]=3)[CH2:12][CH2:13]2)[C:39]2[C:34](=[CH:35][CH:36]=[C:37]([F:40])[CH:38]=2)[NH:33][C:32]1=[O:41])[CH3:29]

Participants

3

Reactant 2

HCID 13421-(1-Naphthyl)piperazineHCID 146011683-(ethylthio)-5-fluoro-3-(2-hydroxyethyl)-1,3-dihydro-2(2H)-indolone tosylate

Product 1

HCID 146011823-Ethylthio-5-fluoro-3-(2-[4-(1-naphthyl)-1-piperazinyl]ethyl}-1,3-dihydro-2(2H)-indolone

Procedure

The product is obtained by following the procedure described under 1.3, starting with 31.6 g (0.148 mole) of 1-naphthylpiperazine and 30.5 g (0.074 mole) of 3-(ethylthio)-5-fluoro-3-(2-hydroxyethyl) -1,3-dihydro-2(2H)-indolone tosylate.

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-1b04e9ea888d4a12a0df5908be4eb0ba
Source dataset
uspto-grants-1991_04
Patent number
US05010079

Reaction notes

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