Methyl iodide → HCID 14601198, compound

HRID 1085405Notes

Reaction equation

[CH2:1]([S:3][C:4]1([CH3:15])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[NH:6][C:5]1=[O:14])[CH3:2].[H-].[Na+].[CH3:18]I>>[CH2:1]([S:3][C:4]1([CH3:15])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[N:6]([CH3:18])[C:5]1=[O:14])[CH3:2]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 14601197HCID 14601197, compound

Product 1

HCID 14601198HCID 14601198, compound

Procedure

11.3 g (0.05 mole) of 3-(ethylthio)-5-fluoro-3-methyl-1,3-dihydro-2(2H)-indolone are methylated as described under 2.2, starting with 2.6 g (0.055 mole) of 50% strength NaH and 3.7 ml of methyl iodide.

Sources & evidence

ORD record: ord-95348c34aee1433c8085c0c8a160303a
Source dataset: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05010079

Reaction notes

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