Hydrochloric Acid → 6-(4-Hydroxypiperidino)carbostyril hydrochloride

HRID 1085469Notes

Reaction equation

HRID 1085469 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1.[ClH:19]>CO>[ClH:19].[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 104669946-(4-Hydroxypiperidino)carbostyril

Product 1

HCID 200601536-(4-Hydroxypiperidino)carbostyril hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

6-(4-Hydroxypiperidino)carbostyril, 0.1 g (0.002 mole), was suspended in 15 mL methanol. Five mL ethanolic hydrogen chloride was added and the mixture digested on a steam bath for 15 minutes until part of the methanol had evaporated. After cooling, filtration and washing with ethyl acetate, the resulting white crystals, 0.05 g, were recrystallized by dissolving in warm methanol and adding ethyl acetate. The yield was 0.05 g 6-(4-hydroxypiperidino)carbostyril hydrochloride; m.p. 259°-262° C.

Workup

  1. customhad evaporated
  2. temperatureAfter cooling
  3. filtrationfiltration
  4. washwashing with ethyl acetate
  5. customthe resulting white crystals, 0.05 g, were recrystallized
  6. dissolutionby dissolving in warm methanol
  7. additionadding ethyl acetate

Sources & evidence

ORD record
ord-4ca302c327e341f686b861e62fdd0b24
Source dataset
uspto-grants-1991_04
Patent number
US05010088

Reaction notes

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