反应详情

温度

100 °C

A mixture of 6-(4-hydroxypiperidino)carbostyril (0.25 g), benzoyl chloride (0.17 g) and dry pyridine (2 mL) was heated for 3 hours at 100° C. The reaction mixture was cooled and water (about 25 mL) and sodium bicarbonate (1 g) were added. The mixture was chilled in ice and stirred. The resulting solid was removed by filtration, washed with water and dried to give crude 6-(4-benzoyloxypiperidino)-2(1H)-quinolinone (0.25 g). Recrystallization twice from ethyl acetate gave 6-(4-benzoyloxypiperidino)-2(1H)-quinolinone (0.18 g); m.p. 212°-215° C.

1. temperatureThe reaction mixture was cooled
2. temperatureThe mixture was chilled in ice
3. customThe resulting solid was removed by filtration
4. washwashed with water
5. customdried
6. customto give crude 6-(4-benzoyloxypiperidino)-2(1H)-quinolinone (0.25 g)
7. customRecrystallization twice from ethyl acetate