Sodium Hydroxide → HCID 54119850, compound

HRID 1085572Notes

Reaction equation

HRID 1085572 reaction equation
[CH3:1][C:2]1([CH3:9])[C:6](=[O:7])[CH:5]=[C:4]([CH3:8])[O:3]1.[C:10]([C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=1)#[N:11].[OH-].[Na+]>C(O)C.[Cl-].[Na+]>[CH3:1][C:2]1([CH3:9])[C:6](=[O:7])[CH:5]=[C:4]([CH:8]=[CH:16][C:15]2[CH:18]=[CH:19][C:12]([C:10]#[N:11])=[CH:13][CH:14]=2)[O:3]1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 660424-CyanobenzaldehydeHCID 1370803(2H)-Furanone, 2,2,5-trimethyl-

Product 1

HCID 54119850HCID 54119850, compoundYield 53%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 5234Sodium ChlorideSolvent

Procedure

A solution of 2,2,5-trimethyl-3(2H)-furanone (1.5 g, 11.9 mM), 4-cyanobenzaldehyde (1.7 g, 13.1 mM) and 1N aqueous sodium hydroxide (1.2 mL, 1.2 mM) in ethanol (50 mL) was stirred 24 hours at room temperature. The reaction mixture was diluted with saturated aqueous sodium chloride (200 mL) and extracted with diethyl ether (3×100 mL). The combined ethereal extracts were washed with saturated aqueous sodium chloride (50 mL), dried over MgSO4, filtered and concentrated under reduced pressure to give a yellow solid. The crude product was purified by column chromatography (silica gel, 9:1, hexane-ethyl acetate) to afford pale yellow crystals (1.5 g, 53% yield), m.p. 169.5°-170.5° C.

Workup

  1. extractionextracted with diethyl ether (3×100 mL)
  2. washThe combined ethereal extracts were washed with saturated aqueous sodium chloride (50 mL)
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customto give a yellow solid
  7. customThe crude product was purified by column chromatography (silica gel, 9:1, hexane-ethyl acetate)

Sources & evidence

ORD record
ord-c647c6652b3b4086940c7cc2be5dd4e8
Source dataset
uspto-grants-1991_04
Patent number
US05010102

Reaction notes

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