Water → HCID 15753009, compound

HRID 1085601Notes

Reaction equation

HRID 1085601 reaction equation
[Br:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=2)=[C:4]([C:15]#[N:16])[CH:3]=1.[Cl:17]OC(C)(C)C.O.BrC1NC(C2C=CC(Cl)=C(Cl)C=2)=C([N+]([O-])=O)C=1>O1CCCC1>[Br:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=2)=[C:4]([C:15]#[N:16])[C:3]=1[Cl:17]

Participants

6

Reactant 4

HCID 962WaterHCID 521297Tert-Butyl hypochloriteHCID 15753013HCID 15753013, compoundHCID 19381313HCID 19381313, compound

Product 1

HCID 15753009HCID 15753009, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A sample of 5-bromo-2-(3,4-dichlorophenyl)pyrrole-3-carbonitrile (0.158 g, 0.005 mole) is dissolved in tetrahydrofuran (5 mL). An equivalent amount of t-butyl hypochlorite is added and the solution stirred overnight. The solution is poured into water and the precipitate (0.052 g, 30%) is collected. The mp is >275° C. In a similiar fashion one can prepare 2-bromo-3-chloro-5-(3,4-dichlorophenyl)-4-nitropyrrole by starting with 2-bromo-5-(3,4-dichlorophenyl)-4-nitropyrrole.

Workup

  1. customthe precipitate (0.052 g, 30%) is collected
  2. customIn a similiar fashion one can prepare 2-bromo-3-chloro-5-(3,4-dichlorophenyl)-4-nitropyrrole

Sources & evidence

ORD record
ord-3dbf979cd9244fd99b4cadb7d3ed71d5
Source dataset
uspto-grants-1991_04
Patent number
US05010098

Reaction notes

Loading…