HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Xylyl isocyanate → 1-(2,6-Dimethylphenylaminocarbonyl)-3-isopropylhexahydropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Xylyl isocyanate | HCID 98787 | — |
| Reactant | N-isopropylhexahydropyrimidine | HCID 12676275 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(2,6-Dimethylphenylaminocarbonyl)-3-isopropylhexahydropyrimidine | HCID 14833044 | — |
Reaction Steps
2,6-Dimethylphenylisocyanate (1.5 g) was added dropwise to a solution of N-isopropylhexahydropyrimidine (1.3 g) in acetonitrile (5 ml) (exothermic). After cooling the title compound was isolated by filtration and recrystallised from acetonitrile (2,5 g, 89%), mp 138°-139° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05010196 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-6237708d3f074c51a98a82443e02ed8d |
| Source note | uspto-grants-1991_04 |