Sodium Hydroxide → 2-t-Butyl-5-hydroxy-1,4,5,6-tetrahydropyrimidine

HRID 1085644Notes

Reaction equation

HRID 1085644 reaction equation
Cl.[C:2]([C:6]1[NH:11][CH2:10][CH:9]([OH:12])[CH2:8][N:7]=1)([CH3:5])([CH3:4])[CH3:3].[OH-].[Na+]>O>[C:2]([C:6]1[NH:11][CH2:10][CH:9]([OH:12])[CH2:8][N:7]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 198123535-Pyrimidinol, 2-(1,1-dimethylethyl)-1,4,5,6-tetrahydro-, hydrochloride (1:1)

Product 1

HCID 110948792-t-Butyl-5-hydroxy-1,4,5,6-tetrahydropyrimidineYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

57.7 g (0.3 mol) of 2-tert-butyl-5-hydroxy-3,4,5,6-tetrahydropyrimidine hydrochloride are dissolved in 100 ml of water and 20 ml of 45 percent strength sodium hydroxide solution are added. The precipitated product is filtered off with suction. 32.7 g (70% of theory) of 2-tert-butyl-5-hydroxy-3,4,5,6-tetrahydropyrimidine are thus obtained in the form of colorless crystals having melting point 210° C.

Workup

  1. filtrationThe precipitated product is filtered off with suction

Sources & evidence

ORD record
ord-d3da283de6ed4b20997b8a748d1f5bac
Source dataset
uspto-grants-1991_04
Patent number
US05010193

Reaction notes

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