HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-t-Butyl-5-hydroxy-1,4,5,6-tetrahydropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Pyrimidinol, 2-(1,1-dimethylethyl)-1,4,5,6-tetrahydro-, hydrochloride (1:1) | HCID 19812353 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-t-Butyl-5-hydroxy-1,4,5,6-tetrahydropyrimidine | HCID 11094879 | 70% |
Reaction Steps
57.7 g (0.3 mol) of 2-tert-butyl-5-hydroxy-3,4,5,6-tetrahydropyrimidine hydrochloride are dissolved in 100 ml of water and 20 ml of 45 percent strength sodium hydroxide solution are added. The precipitated product is filtered off with suction. 32.7 g (70% of theory) of 2-tert-butyl-5-hydroxy-3,4,5,6-tetrahydropyrimidine are thus obtained in the form of colorless crystals having melting point 210° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05010193 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-d3da283de6ed4b20997b8a748d1f5bac |
| Source note | uspto-grants-1991_04 |