反应详情

温度

70 °C

A mixture of 2.3 parts of [2-(4-methoxyphenyl)ethyl] methanesulfonate, 4 parts of N-(4-piperidinyl)-2-benzothiazolamine dihydrobromide, 5.3 parts of sodium carbonate, 0.1 parts of potassium iodide and 90 parts of N,N-dimethylformamide was stirred overnight at 70° C. The reaction mixture was poured onto water and the product was extracted with methylbenzene. The extract was washed with water, dried, filtered and evaporated. The residue was crystallized from a mixture of 2-propanol and 2,2'-oxybispropane. The product was filtered off and dried, yielding 1.5 parts (41%) of N-[1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinyl]-2-benzothiazolamine; mp. 142.5° C. (178).

1. additionThe reaction mixture was poured onto water
2. extractionthe product was extracted with methylbenzene
3. washThe extract was washed with water
4. customdried
5. filtrationfiltered
6. customevaporated
7. customThe residue was crystallized from a mixture of 2-propanol and 2,2'-oxybispropane
8. filtrationThe product was filtered off
9. customdried