Guanidine Hydrochloride → HCID 14718745, compound

HRID 1085707Notes

Reaction equation

HRID 1085707 reaction equation
C[O-].[Na+].Cl.[NH2:5][C:6]([NH2:8])=[NH:7].CN(C)[CH:11]=[C:12]([CH:22]=O)[CH:13]([CH:19]([CH3:21])[CH3:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(O)C>[NH2:7][C:6]1[N:8]=[CH:11][C:12]([CH:13]([CH:19]([CH3:20])[CH3:21])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:22][N:5]=1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 54210763ethyl (RS)-4-dimethylamino-3-formyl-2-(1-methylethyl)-3-butenoate

Product 1

HCID 14718745HCID 14718745, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of sodium methoxide (0.9 g) in ethanol (5 cm3) was added dropwise to a stirred suspension of guanidine hydrochloride (1.58 g) and ethyl (RS)-4-dimethylamino-3-formyl-2-(1-methylethyl)-3-butenoate in ethanol (10 cm3). The reaction mixture was heated at the reflux temperature for 2 hours, then stood at the ambient temperature for 70 hours. The solvent was evaporated under reduced pressure and water added to the residue.

Workup

  1. temperatureThe reaction mixture was heated at the reflux temperature for 2 hours
  2. customThe solvent was evaporated under reduced pressure and water
  3. additionadded to the residue

Sources & evidence

ORD record
ord-6790dc93d638455f936ed00efb37a162
Source dataset
uspto-grants-1991_04
Patent number
US05010200

Reaction notes

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