HCID 14718905, compound → HCID 14718769, compound

HRID 1085721Notes

Reaction equation

HRID 1085721 reaction equation
O1CCCCC1[O:7][CH2:8][C:9]1[C:14]([F:15])=[C:13]([F:16])[C:12]([CH2:17][CH:18]2[CH2:20][C:19]2([Cl:22])[Cl:21])=[C:11]([F:23])[C:10]=1[F:24]>CO.Cl>[Cl:22][C:19]1([Cl:21])[CH2:20][CH:18]1[CH2:17][C:12]1[C:11]([F:23])=[C:10]([F:24])[C:9]([CH2:8][OH:7])=[C:14]([F:15])[C:13]=1[F:16]

Participants

4

Reactant 1

HCID 14718905HCID 14718905, compound

Product 1

HCID 14718769HCID 14718769, compoundYield 79.8%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

4-[(2,2-dichlorocyclopropyl)methyl]-2,3,5,6-tetrafluorobenzyl tetrahydropyran-2-yl ether (0.240 g) was heated at the reflux temperature for 3 hours in a mixture of methanol (5 cm3) and 2 M hydrochloric acid (1 cm3). The solvent was evaporated under reduced pressure and water removed azeotropically from the sample by heating with toluene (2×10 cm3). The title product (0.15 g) was obtained as an orange oil.

Workup

  1. customThe solvent was evaporated under reduced pressure and water
  2. customremoved azeotropically from the sample
  3. temperatureby heating with toluene (2×10 cm3)

Sources & evidence

ORD record
ord-45c2d99270ea4d149af9617a5a1663a8
Source dataset
uspto-grants-1991_04
Patent number
US05010200

Reaction notes

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