Cyanogen Bromide → HCID 15107886, compound

HRID 1085775Notes

Reaction equation

HRID 1085775 reaction equation
[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([NH:12][NH2:13])=[N:4][N:3]=1.C([O-])(=O)C.[Na+].[N:19]#[C:20]Br>CO>[NH2:19][C:20]1[N:4]2[N:3]=[C:2]([Cl:1])[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]2=[N:12][N:13]=1

Participants

5

Reactant 3

HCID 10476Cyanogen BromideHCID 517045Sodium AcetateHCID 640098866597-78-2

Product 1

HCID 15107886HCID 15107886, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 46.88 gm (0.236 mole) quantity of 1-chloro-4-hydrazino5,6,7,8-tetrahydrophthalazine was added to 450 ml of methanol. A 40.8 gm quantity of sodium acetate and 25.0 gm of cyanogen bromide was added and the mixture was stirred on a warm plate for 30 minutes. Yellow crystals appeared immediately. The mixture was allowed to sit for 3 days. The resulting solid was filtered, washed with ether, and dried, yielding 44.85 gm of 3-amino-6-chloro-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine; mp 224-225° C. (ethanol).

Workup

  1. waitto sit for 3 days
  2. filtrationThe resulting solid was filtered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-97d0a16047ce42a3989ca1f536f1bb0a
Source dataset
uspto-grants-1991_04
Patent number
US05011835

Reaction notes

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