Morpholine → HCID 15107893, compound

HRID 1085777Notes

Reaction equation

HRID 1085777 reaction equation
[NH2:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[C:9]3[CH2:10][CH2:11][CH2:12][CH2:13][C:14]=3[C:5]2=[N:4][N:3]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[NH2:1][C:2]1[N:6]2[N:7]=[C:8]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[C:9]3[CH2:10][CH2:11][CH2:12][CH2:13][C:14]=3[C:5]2=[N:4][N:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 15107886HCID 15107886, compound

Product 1

HCID 15107893HCID 15107893, compound

Procedure

A 22.40 gm (0.100 mole) quantity of 3-amino-6-chloro-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine was added to 225 ml of morpholine and the mixture was refluxed for 7 hours. The mixture was then evaporated. A 250 ml volume of water was added to the residue and the mixture was stirred. The resulting solid was filtered and dried, yielding 27.2 gm of 3-amino-6-(4-morpholinyl)-7,8,9,10-tetrahydro-1,2,4triazolo [3,4-a]phthalazine; mp 260-262° C.

Workup

  1. temperaturethe mixture was refluxed for 7 hours
  2. customThe mixture was then evaporated
  3. additionA 250 ml volume of water was added to the residue
  4. filtrationThe resulting solid was filtered
  5. customdried

Sources & evidence

ORD record
ord-71ab569bd68d4c9883a4cd64b4004b3e
Source dataset
uspto-grants-1991_04
Patent number
US05011835

Reaction notes

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