HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxynaphthalen-1-ylmethylamine → 4,6-Dichloro-5-(4-methoxy-1-naphthylmethylamino)-3(2H)pyridazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxynaphthalen-1-ylmethylamine | HCID 59139 | — |
| Reactant | 3,4,5-Trichlor-6-hydroxypyridazin | HCID 11106349 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4,6-Dichloro-5-(4-methoxy-1-naphthylmethylamino)-3(2H)pyridazinone | HCID 9884758 | — |
Reaction Steps
A mixture comprising 800 mg of 4,5,6-trichloro-3(2H)pyridazinone, 2.68 g of 4-methoxy-1-naphthylmethylamine and 10 ml of ethanol, was refluxed under stirring for 4 hours. After cooling, precipitated crystals were collected by filtration. Then, the product was dissolved in hot ethyl acetate and treated by silica gel. The filtrate was concentrated, and precipitated crystals were collected by filtration to obtain 330 mg of the above identified compound as colorless crystals having a melting point of from 228° to 231° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05011839 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-f83b4264c56b4aef9b9b6fb6f5dcebcc |
| Source note | uspto-grants-1991_04 |