反应详情

4.3 g (12.37 mmol) of t-butyl [2-(5-phenyl-4-thiazolecarboxamido)ethyl]carbamate were dissolved in 10 ml of methylene chloride, treated with 5.0 ml of trifluoro-acetic acid and stirred at 20° for 16 hours and at 60° for 1 hour. Subsequently, the mixture was concentrated under reduced pressure. The residue was dissolved in 10 ml of ethanol, treated with 3 ml of 17.5% (w/v) ethanolic hydro-chloric acid and evaporated. The residue was recrystallized from methanol, whereby 3.3 g (94%) of N-(2-aminoethyl)-5-phenyl-4-thiazolecarboxamide hydrochloride were obtained as white crystals, melting point 243°-245°.

1. concentrationSubsequently, the mixture was concentrated under reduced pressure
2. dissolutionThe residue was dissolved in 10 ml of ethanol
3. additiontreated with 3 ml of 17.5% (w/v) ethanolic hydro-chloric acid
4. customevaporated
5. customThe residue was recrystallized from methanol