Propylamine → 2-Pyrimidinamine, 4,6-difluoro-N-propyl-

HRID 1085888Notes

Reaction equation

HRID 1085888 reaction equation
[CH2:1]([NH2:4])[CH2:2][CH3:3].F[C:6]1[N:11]=[C:10]([F:12])[CH:9]=[C:8]([F:13])[N:7]=1>C(OCC)C>[F:13][C:8]1[CH:9]=[C:10]([F:12])[N:11]=[C:6]([NH:4][CH2:1][CH2:2][CH3:3])[N:7]=1

Participants

4

Reactant 2

HCID 7852PropylamineHCID 696772,4,6-Trifluoropyrimidine

Product 1

HCID 97939782-Pyrimidinamine, 4,6-difluoro-N-propyl-

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
25 °C

Procedure

13.0 g (0.22 mol) of n-propylamine were added at -20° C. to a mixture of 13.4 g (0.1 mol) of 2,4,6-trifluoropyrimidine in 150 ml of diethyl ether within 20 minutes. After stirring at -20° C. for 1 hour and at 25° C. for 1 hour, the precipitate was filtered off, and the organic phase was washed with water, dried and concentrated under reduced pressure. 15.8 g (91.3% of theory) of the title compound were obtained as an oil (nD23 =1.4965).

Workup

  1. filtrationthe precipitate was filtered off
  2. washthe organic phase was washed with water
  3. customdried
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2f09801935844f3488e2f94780d3c179
Source dataset
uspto-grants-1991_04
Patent number
US05011927

Reaction notes

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