反应详情

温度

25 °C

335.8 g (1.865 mol) of 30% strength sodium methylate (in methanol) were added at -20° C. to a mixture of 250 g (1.865 mol) of 2,4,6-trifluoropyrimidine in 1.4 1 of methanol within 45 minutes, and the mixture was stirred at this temperature for a further 30 minutes. The reaction mixture was then allowed to warm to 25° C. and concentrated to about 1/5 of its volume.

1. concentrationconcentrated to about 1/5 of its volume