2,4,6-Trifluoropyrimidine → 2,4-Difluoro-6-methoxypyrimidine

HRID 1085890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1085890
[CH3:1][O-:2].[Na+].[F:4][C:5]1[N:10]=[C:9]([F:11])[CH:8]=[C:7](F)[N:6]=1>CO>[F:4][C:5]1[N:10]=[C:9]([F:11])[CH:8]=[C:7]([O:2][CH3:1])[N:6]=1

Komponenten

4

Edukt 2

HCID 696772,4,6-TrifluoropyrimidineHCID 10942334Sodium Methoxide

Produkt 1

HCID 111264032,4-Difluoro-6-methoxypyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

335.8 g (1.865 mol) of 30% strength sodium methylate (in methanol) were added at -20° C. to a mixture of 250 g (1.865 mol) of 2,4,6-trifluoropyrimidine in 1.4 1 of methanol within 45 minutes, and the mixture was stirred at this temperature for a further 30 minutes. The reaction mixture was then allowed to warm to 25° C. and concentrated to about 1/5 of its volume.

Aufarbeitung

  1. concentrationconcentrated to about 1/5 of its volume

Quellen und Nachweise

ORD-Eintrag
ord-4d1f480acd334555a9e7abb1aceb558f
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05011927

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