Hexylamine → 4-Fluoro-2-n-hexylamino-6-methoxypyrimidine

HRID 1085894노트

반응식

[CH2:1]([NH2:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].F[C:9]1[N:14]=[C:13]([F:15])[CH:12]=[C:11]([O:16][CH3:17])[N:10]=1.C(OCCCC)CCC>>[F:15][C:13]1[CH:12]=[C:11]([O:16][CH3:17])[N:10]=[C:9]([NH:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[N:14]=1

참가 물질

반응물 3

HCID 8102Hexylamine

HCID 8909Butyl ether

HCID 111264032,4-Difluoro-6-methoxypyrimidine

생성물 1

HCID 147172354-Fluoro-2-n-hexylamino-6-methoxypyrimidine

실험 절차

15.6 g (0.154 mol) of n-hexylamine were added at 0° to 2° C. to a stirred mixture of 10.4 g (0.071 mol) of 2,4-difluoro-6-methoxypyrimidine in 60 ml of methyl t.-butyl ether within 15 minutes. After 1 hour at 0° C., 4 hours at 25° C. and working up as in B 2-3, 9.6 g (60% of theory) of the title compound of nD23 =1.4938 were obtained.

후처리

custom4 hours
customat 25° C.

출처 및 근거

ORD 기록: ord-24f3527ce3ea4e1eb30070769fa937c0
출처 데이터셋: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05011927

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