5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide → Flosequinoxan

HRID 1085907Notes

Reaction equation

HRID 1085907 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>C(O)(C)C>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 867447425'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide

Product 1

HCID 131270Flosequinoxan

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (1.0 g), prepared in a similar manner to that described in Example 11, in isopropyl alcohol (20 ml) was heated to reflux for 3.5 hours. The mixture was cooled to ambient temperature and the product collected by filtration and dried in vacuo at 50° to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 234.5°-235° (0.6 g).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3.5 hours
  3. filtrationthe product collected by filtration
  4. customdried in vacuo at 50°

Sources & evidence

ORD record
ord-df2c07268b5c48a69f05553f8fb6dcab
Source dataset
uspto-grants-1991_04
Patent number
US05011931

Reaction notes

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