反应详情

1.2 g of sodium methylsulfinate are introduced into a solution of 2.02 g of ethyl 4-chloro-2-oxo-2H-pyran-5-carboxylate in DMF, and the mixture is stirred for 2 hours at room temperature. The reaction mixture is diluted with CH2Cl2 and extracted with saturated aqueous NaCl solution. The organic phase is dried with Na2SO4 and evaporated. The distillation residue which has crystallized out is mixed with ether, filtered off with suction and washed with ether. Yield 1.4 g (56.9% of theory); melting point: 95°-97° C.

1. extractionextracted with saturated aqueous NaCl solution
2. dry with materialThe organic phase is dried with Na2SO4
3. customevaporated
4. customThe distillation residue which has crystallized out
5. additionis mixed with ether
6. filtrationfiltered off with suction
7. washwashed with ether