Benzoylhydrazine → HCID 54495306, compound

HRID 1085938Notes

Reaction equation

HRID 1085938 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)(=O)[CH2:2][CH3:3].[C:11]([NH:19][NH2:20])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(O)C>[N:8]1[CH:9]=[CH:10][C:5]([C:1](=[N:20][NH:19][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:2][CH3:3])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 11955BenzoylhydrazineHCID 743431-(4-Pyridinyl)-1-propanone

Product 1

HCID 54495306HCID 54495306, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4.05 gm (0.03 mole) of 4-propionylpyridine, 4.08 gm (0.03 mole) of benzhydrazide and 100 ml of Ethanol is refluxed 6 hr. The hot solution is filtered. The filtrate is cooled to room temperature and then chilled in the refrigerator. The product is collected, washed with Skellysolve B and dried to yield 5.36 gm (71%) of the title compound having a melting point of 177.6° C.

Workup

  1. temperatureis refluxed 6 hr
  2. filtrationThe hot solution is filtered
  3. temperaturechilled in the refrigerator
  4. customThe product is collected
  5. washwashed with Skellysolve B
  6. customdried

Sources & evidence

ORD record
ord-9decf4c024d34462bc979172ba694e9b
Source dataset
uspto-grants-1991_04
Patent number
US05011932

Reaction notes

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