4-Benzoylpyridine → HCID 54141737, compound

HRID 1085945Notes

Reaction equation

HRID 1085945 reaction equation
[C:1]([O:5][C:6](=[O:9])[NH:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[C:10]([C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)(=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O.C(O)C>[N:21]1[CH:22]=[CH:23][C:18]([C:10](=[N:8][NH:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:9])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:19][CH:20]=1

Participants

5

Reactant 2

HCID 267314-BenzoylpyridineHCID 70091tert-Butyl carbazate

Product 1

HCID 54141737HCID 54141737, compoundYield 12%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To 6.61 gm (0.05 mole) of t-butylcarbazate dissolved in 100 ml of warm water is added 9.16 gm (0.05 mole) of 4-benzoylpyridine in 30 ml of ethanol. The mixture is refluxed 7 hr. Cooling several weeks yields 1.77 gm (12%) of the title compound having a melting point of 134.5° C.

Workup

  1. temperatureThe mixture is refluxed 7 hr
  2. temperatureCooling several weeks

Sources & evidence

ORD record
ord-cde0f8e43ee441b68ae8352947b7fea7
Source dataset
uspto-grants-1991_04
Patent number
US05011932

Reaction notes

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