Cyclopropanecarbohydrazide → Cyclopropanecarboxylic acid [1-(6-chloro-3-pyridinyl)ethylidene]hydrazide

HRID 1085976Notes

Reaction equation

HRID 1085976 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][C:7]([Cl:10])=[CH:8][CH:9]=1)(=O)[CH3:2].[CH:11]1([C:14]([NH:16][NH2:17])=[O:15])[CH2:13][CH2:12]1>C(O)C>[Cl:10][C:7]1[N:6]=[CH:5][C:4]([C:1](=[N:17][NH:16][C:14]([CH:11]2[CH2:13][CH2:12]2)=[O:15])[CH3:2])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 81396CyclopropanecarbohydrazideHCID 27796981-(6-Chloropyridin-3-yl)ethan-1-one

Product 1

HCID 53866309Cyclopropanecarboxylic acid [1-(6-chloro-3-pyridinyl)ethylidene]hydrazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the general method of procedure 53 and making non-critical variations, except the product was purified by recrystallization from absolute ethanol rather than by chromatography, 5.25 gm (0.0337 mole) of 3-acetyl-6-chloropyridine and 3.40 gm (0.034 mole) of cyclopropanecarboxylic acid hydrazide yield 6.52 gm (81%) of the title compound having a melting point of 218.1° C.

Sources & evidence

ORD record
ord-3e26f3baca9f4c03be0fc3a931816e59
Source dataset
uspto-grants-1991_04
Patent number
US05011932

Reaction notes

Loading…